Molecular Epidemiology of HCV Infection among Multi-Transfused β-Thalassemia Patients in Eastern India: A Six-Year Observation

نویسندگان

چکیده

Background: HCV infection is very common in multi-transfused β-thalassemia patients who need regular blood transfusions. Aim: The study was conducted to determine the epidemiology of West Bengal, India. Methods: Over a span six years, samples were collected from sero-reactive and processed for viral RNA isolation followed by nested RT-PCR qualitative viremia detection. genotype determined amplifying partial core gene DNA sequencing NCBI genotyping tools. Phylogenetic phylogeographic studies performed with MEGA-X BEAST software, respectively. Results: Out 917 patients, 598 (65.21%) positive while 250 (41.80%) had spontaneously cleared virus. A significant percentage male rural areas (p = 0.042) economically backward class 0.002) at higher risk infection. Female thalassemia individuals belonging ages 11–15 years chances spontaneous clearance. most prevalent circulatory 3a (78.26%) 1b (12.04%). Phylogeographic analyses revealed that strains share genomic similarities Pakistan, Sri Lanka, Thailand, whereas Vietnam, Russia, China. Uncommon subtypes 3g 3i also detected. Conclusion: high prevalence among India indicates NAT-based assays should be implemented screening donor eliminate 2030.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Prevalence of Anti-hcv, Hbsag, Hiv among Multi-transfused Thalassemic Individuals and Their Socio-economic Background in Eastern India

Objective: The objective was to study the serological prevalence of post-transfusion transmitted infections such as hepatitis C virus (HCV), hepatitis B virus (HBV), and HIV among multi-transfused thalassemic individuals of the Eastern India and the socio and financial difficulties faced by them. Methods: The study was carried out from January 2012 until December 2014 involving 1711 thalassemic...

متن کامل

Red Blood Cells Alloimmunization and Autoimmunization in Multi-transfused Thalassemia Patients in South of Iran

Background: Recurrent blood transfusion is a common treatment in patients with thalassemia. The development of antibodies against red blood cell (RBC) antigens complicates RBC cross-matching, enhances the in vivo destruction of transfused cells, accelerates tissue iron overloading, delays the provision of safe transfusion, and reduces health-related quality of life. Materials and Methods: In t...

متن کامل

seroprevalence of hcv antibody among patients with β-thalassemia major in amirkola thalassemia center, iran

β- thalassemia major is a common hemoglobinopathy in humans. in some journals, numerous studies have reported different prevalence of hepatitis c among β- thalassemia major because thalassemic patients need multiple blood transfusions and blood transfusion is a common transmission pathway for hepatitis c virus. thus this study was performed for detection of anti-hcv between β- thalassemia major...

متن کامل

Molecular epidemiology of β-thalassemia in Pakistan: Far reaching implications

β-thalassaemia, an autosomal recessive hemoglobinopathy, is one of the commonest genetically transmitted disorders throughout the world. Collective measures including carrier identification, genetic counseling and prenatal diagnosis are required for preventing β-thalassemia. To achieve this objective, Identification of the spectrum of genetic mutations, especially for various ethnic backgrounds...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Thalassemia Reports

سال: 2023

ISSN: ['2039-4357', '2039-4365']

DOI: https://doi.org/10.3390/thalassrep13030016